| All Saturdays - All Branches Closed | | |
| All Sundays - All Branches Closed | | |
| New Year’s Day | Jan. 1, 2021 | Monday |
| Martin Luther King, Jr. Day | Jan. 18, 2021 | Monday |
| President’s Day | Feb. 15, 2021 | Monday |
| Easter (Henderson Branch Only) | April 2, 2021 | Friday |
| Memorial Day | May 31, 2021 | Monday |
| Independence Day | July 5, 2021 | Monday |
| Independence Day (Zebulon-GSK Branch Only) | July 5 – 9, 2021 | Monday – Friday |
| Labor Day | Sep. 6, 2021 | Monday |
| Columbus Day | Oct. 11, 2021 | Monday |
| Veterans Day | Nov. 11, 2021 | Thursday |
| Thanksgiving and Day after Thanksgiving | Nov. 25 – 27, 2021 | Thursday & Friday |
| Christmas — Main, Greenville, Henderson & Zebulon-Gannon Branches | Dec. 24, 2021 | Friday |
| End of Year (Moore Drive-GSK & Zebulon GSK Branches Only) | Dec. 24 – 31, 2021 | Friday – Friday |
| New Year's — Main, Greenville, Henderson & Zebulon-Gannon Branches | Dec. 31, 2021 | Friday |
