| All Saturdays - All Branches Closed | | |
| All Sundays - All Branches Closed | | |
| Martin Luther King, Jr. Day | Jan. 17, 2022 | Monday |
| President’s Day | Feb. 21, 2022 | Monday |
| Good Friday (Henderson Branch Only) | April 15, 2022 | Friday |
| Memorial Day | May 30, 2022 | Monday |
| Juneteenth Day | June 20, 2022 | Monday |
| Independence Day | July 4, 2022 | Monday |
| Independence Day (Zebulon-GSK Branch Only) | July 5 – 8, 2022 | Tuesday – Friday |
| Labor Day | Sep. 5, 2022 | Monday |
| Columbus Day | Oct. 10, 2022 | Monday |
| Veterans Day | Nov. 11, 2022 | Friday |
| Thanksgiving and Day after Thanksgiving | Nov. 24 – 25, 2022 | Thursday & Friday |
| Christmas (observed) — Henderson Branch | Dec. 23, 2022 | Friday |
| Christmas Day (observed) | Dec. 26, 2022 | Monday |
| Winter Shutdown (Zebulon GSK) | Dec. 27 – 30, 2022 | Tuesday – Friday |
| New Years Eve (observed) — Henderson | Dec. 30, 2022 | Friday |
